6/29/2023 0 Comments Lightpaper rohinniActivation of corticostriatal circuitry relieves chronic neuropathic pain. A neuroimaging biomarker for sustained experimental and clinical pain. A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. An amygdalar neural ensemble that encodes the unpleasantness of pain. Corticostriatal functional connectivity predicts transition to chronic back pain. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. An fMRI-based neurologic signature of physical pain. Pain-related neurons in the human cingulate cortex. Neural correlates of interindividual differences in the subjective experience of pain. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. BEST (Biomarkers, EndpointS, and other Tools) Resource (FDA, 2016).ĭavis, K. Wide-Ranging Online Data for Epidemiologic Research (WONDER) (Centers for Disease Control and Prevention, 2016) įDA-NIH Biomarker Working Group. Thus, intracranial OFC signals can be used to predict spontaneous, chronic pain state in patients. Chronic pain decoding relied on sustained power changes from the OFC, which tended to differ from transient patterns of activity associated with acute, evoked pain states during a task. We successfully predicted intraindividual chronic pain severity scores from neural activity with high sensitivity using machine learning methods. Participants reported pain metrics coincident with ambulatory, direct neural recordings obtained multiple times daily over months. Here four individuals with refractory neuropathic pain were implanted with chronic intracranial electrodes in the anterior cingulate cortex and orbitofrontal cortex (OFC). Also, which brain activity underlies chronic pain on clinically relevant timescales, or how this relates to acute pain, remains unclear. Pain severity is often measured through subjective report, while objective biomarkers that may guide diagnosis and treatment are lacking. © 2023 USPTO.Chronic pain syndromes are often refractory to treatment and cause substantial suffering and disability. Any reliance you place on such information is therefore strictly at your own risk.Īll official trademark data, including owner information, should be verified by visiting the official USPTO website at This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law. The use of this site is at your own risk. While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only. Uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. NOTIFICATION OF NOTICE OF UNRESPONSIVE AMENDMENT - E-MAILEDĪBANDONMENT - FAILURE TO RESPOND OR LATE RESPONSEĪBANDONMENT NOTICE MAILED - FAILURE TO RESPOND NOTICE OF UNRESPONSIVE AMENDMENT - E-MAILED REPORT UNRESPONSIVE AMENDMENT - COMPLETED TEAS REVOKE/APP/CHANGE ADDR OF ATTY/DOM REP RECEIVEDĪTTORNEY/ AND/OR APPOINTED NOTIFICATION OF NON-FINAL ACTION E-MAILED NEW APPLICATION OFFICE SUPPLIED DATA ENTERED IN TRAM
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